HeLa nucleic acid contamination in The Cancer Genome Atlas leads to the 1 misidentification of HPV 18
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چکیده
HeLa nucleic acid contamination in The Cancer Genome Atlas leads to the 1 misidentification of HPV18 2 3 Paul G. Cantalupo, Joshua P. Katz, James M. Pipas# 4 5 Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 6 7 Running title: HeLa contamination in TCGA misidentifies HPV18 8 9 # Corresponding author: James Pipas, [email protected]. 10 11 Abstract word count: 147 12 Text word count: 3061 13 14 15 JVI Accepted Manuscript Posted Online 28 January 2015 J. Virol. doi:10.1128/JVI.03365-14 Copyright © 2015, American Society for Microbiology. All Rights Reserved.
منابع مشابه
HeLa nucleic acid contamination in the cancer genome atlas leads to the misidentification of human papillomavirus 18.
UNLABELLED We searched The Cancer Genome Atlas (TCGA) database for viruses by comparing non-human reads present in transcriptome sequencing (RNA-Seq) and whole-exome sequencing (WXS) data to viral sequence databases. Human papillomavirus 18 (HPV18) is an etiologic agent of cervical cancer, and as expected, we found robust expression of HPV18 genes in cervical cancer samples. In agreement with p...
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تاریخ انتشار 2015